Claimed effect · PT-141

Does PT-141 help with erectile function / use in men?

C
Grade C — weak human evidenceEarlier phase 2 work · effect size: small
Short answerWeak human evidence. Earlier phase 2 work: enough to be interesting, not enough to count on. Where an effect is seen it is a small effect. Developed originally for erectile dysfunction; intranasal programme was stopped over blood-pressure increases. The approved product and indication are for women.

What the studies show

Developed originally for erectile dysfunction; intranasal programme was stopped over blood-pressure increases. The approved product and indication are for women.

A few small or poorly-controlled human studies. Enough to be interesting; not enough to count on. Most of what gets called “clinically proven” online lives here.

  1. 1
    VYLEESI (bremelanotide injection) US prescribing information — RECONNECT phase 3 studies (NCT02333071, NCT02338960).FDA label, initial US approval 20191,267 premenopausal women across two 24-week trials; efficacy and adverse-event figures on this page come from the label.

In context

PT-141, sold as Vyleesi, is a melanocortin-receptor agonist approved in the United States in 2019 for premenopausal women with hypoactive sexual desire disorder. Two phase 3 trials in 1,267 women found statistically significant but small improvements in desire and distress scores against placebo. Nausea affected 40% of participants and 18% stopped because of side effects. Use in men, and for erectile function, is unapproved and far less studied.

PT-141 is approved (rx, us). Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is PT-141 proven to help with erectile function / use in men?
No. The human evidence is weak (Earlier phase 2 work); LYO grades it C.
What studies are behind the grade?
Developed originally for erectile dysfunction; intranasal programme was stopped over blood-pressure increases. The approved product and indication are for women.
Is PT-141 approved for this?
PT-141 is an approved medicine (Approved (Rx, US)); whether this particular outcome is a licensed indication is stated on the compound page's regulation section.

Other outcomes for PT-141

Reviewed 2 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →