Claimed effect · Mazdutide

Does Mazdutide help with blood glucose?

A
Grade A — established in humansDREAMS phase 3 programme · effect size: moderate
Short answerEstablished in humans. DREAMS phase 3 programme point the same way: a moderate effect. DREAMS-1 and DREAMS-2 in type 2 diabetes met their HbA1c endpoints; approved for glycaemic control in China on that basis. DREAMS-3 reported superiority to semaglutide on HbA1c and weight.

What the studies show

DREAMS-1 and DREAMS-2 in type 2 diabetes met their HbA1c endpoints; approved for glycaemic control in China on that basis. DREAMS-3 reported superiority to semaglutide on HbA1c and weight.

Several well-run randomised trials in people, pointing the same way. You can plan around this. It still says nothing about whether the effect is worth the side effects for you.

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In context

Mazdutide is a once-weekly GLP-1/glucagon dual agonist developed by Innovent with Lilly. In the 610-person GLORY-1 trial, published in the New England Journal of Medicine in May 2025, it produced 14.8% weight loss at 48 weeks on 6 mg against 0.5% on placebo; a 9 mg dose reached 18.6% at 60 weeks in GLORY-2. China's regulator approved it for chronic weight management on 27 June 2025 and later for type 2 diabetes. It is not approved in the US, EU or UK.

Mazdutide is approved in china only. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Mazdutide proven to help with blood glucose?
Yes, as far as human trials can show it: DREAMS phase 3 programme. LYO grades this outcome A.
What studies are behind the grade?
DREAMS-1 and DREAMS-2 in type 2 diabetes met their HbA1c endpoints; approved for glycaemic control in China on that basis. DREAMS-3 reported superiority to semaglutide on HbA1c and weight.
Is Mazdutide approved for this?
Mazdutide is an approved medicine (Approved in China only); whether this particular outcome is a licensed indication is stated on the compound page's regulation section.

Other outcomes for Mazdutide

Reviewed 3 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →